Biomedical Research Grants

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-274) targets strategic development wi...

Data Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative U24 Clinical Trial Required)

PAR-24-276 07/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-276) targets strategic development wi...

Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)

PAR-25-268 11/17/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-268) targets strategic development wi...

Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (R03 Clinical Trial Optional)

PAR-25-155 10/19/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-155) targets strategic development wi...

Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required)

PAR-25-254 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-254) targets strategic development wi...

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

PAR-25-144 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-144) targets strategic development wi...

Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

PAR-25-143 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-143) targets strategic development wi...

Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)

PAR-25-233 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-233) targets strategic development wi...

Population Approaches to Reducing Alcohol-related Cancer Risk (R01 Clinical Trial Optional)

PAR-25-221 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-221) targets strategic development wi...

HIV Prevention and Alcohol (R01 Clinical Trials Optional)

PAS-25-208 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAS-25-208) targets strategic development wi...

National Cancer Institute Youth Enjoy Science Research Education Program (R25 Clinical Trial Not Allowed)

RFA-CA-24-026 09/28/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-CA-24-026) targets strategic development...

INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 Clinical Trial Not Allowed)

RFA-OD-24-007 07/01/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-OD-24-007) targets strategic development...

NEI Institutional Mentored Physician Scientist Award (K12 Clinical Trial Optional)

PAR-23-197 06/09/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-197) targets strategic development wi...

National Institute of General Medical Sciences Predoctoral Basic Biomedical Sciences Research Training Program (T32)

PAR-23-228 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-228) targets strategic development wi...

Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)

PA-24-175 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-175) targets strategic development wit...

Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)

PAR-25-286 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-286) targets strategic development wi...

BRAIN Initiative: Production and distribution facilities for brain cell type-specific access reagents (U24 Clinical Trial Not Allowed)

RFA-MH-25-105 07/01/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-MH-25-105) targets strategic development...

Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

PAR-25-101 08/11/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-101) targets strategic development wi...

Substance Use/Substance Use Disorder Dissertation Research Award (R36 Clinical Trials Not Allowed)

PAR-25-347 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-347) targets strategic development wi...

Institutional Training Programs to Advance Translational Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (T32 Clinical Trial Not Allowed)

PAR-25-247 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-247) targets strategic development wi...

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

PAR-25-317 05/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-317) targets strategic development wi...

BRAIN Initiative: Promoting Health for All Through BRAIN Technology Partnerships (R34 - Clinical Trials Not Allowed)

RFA-NS-25-016 06/17/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-25-016) targets strategic development...

Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science (RC2 Clinical Trials Optional)

PAR-25-156 09/28/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-156) targets strategic development wi...

Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)

PAR-25-298 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-298) targets strategic development wi...

Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)

PAR-25-370 11/16/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-370) targets strategic development wi...

Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required)

PAR-26-001 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-001) targets strategic development wi...

Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)

PAR-25-098 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-098) targets strategic development wi...

NIDCD's Mentored Research Education Pathway for Otolaryngology Residents and Medical Students (R25 - Clinical Trial Not Allowed)

PAR-24-127 09/29/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-127) targets strategic development wi...

Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R01 Clinical Trial Optional)

PAR-25-110 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-110) targets strategic development wi...

Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)

PAR-25-111 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-111) targets strategic development wi...

NLM Information Resource Grants to Reduce Health Disparities and Promote Health for All (G08 Clinical Trial Not Allowed)

PAR-24-281 05/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-281) targets strategic development wi...

Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)

PAR-25-311 11/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-311) targets strategic development wi...

Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)

PAR-25-371 11/18/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-371) targets strategic development wi...

Research Experiences and/or Mentoring Networks through Research Education to Enhance Clinician-Scientists' Participation in NIDCDs Research (R25 Clinical Trial Not Allowed)

PAR-25-020 09/29/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-020) targets strategic development wi...

Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)

PAR-25-369 11/18/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-369) targets strategic development wi...

International Research Experiences for Students

24-506 10/26/2026

High-priority technical directive issued by NSF. This initiative (ID: 24-506) targets strategic development within the P...

Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)

PAR-25-378 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-378) targets strategic development wi...

Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Clinical Trials Not Allowed)

RFA-OD-25-003 04/09/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-OD-25-003) targets strategic development...

Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)

PAR-25-383 01/28/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-383) targets strategic development wi...

NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)

PAR-25-333 05/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-333) targets strategic development wi...

Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional)

RFA-OD-25-008 07/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-OD-25-008) targets strategic development...

NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed)

PAR-25-416 06/14/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-416) targets strategic development wi...

Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)

PAR-25-379 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-379) targets strategic development wi...

Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)

PAR-25-415 09/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-415) targets strategic development wi...

Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)

PAR-25-414 09/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-414) targets strategic development wi...

Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)

PA-25-169 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-169) targets strategic development wit...

Division of Molecular and Cellular Biosciences Core Programs

24-539 See Registry

High-priority technical directive issued by NSF. This initiative (ID: 24-539) targets strategic development within the P...

NIA Career Transition Award (K22 Independent Clinical Trial Not Allowed)

PAR-24-120 07/13/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-120) targets strategic development wi...

Awards Supporting Cutting-Edge Technologies for Translational Science (ASCETTS) (R21 Clinical Trials Not Allowed)

PAR-25-157 06/18/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-157) targets strategic development wi...

Animal Food Regulatory Program Standards Implementation Development and Maintenance, with Mutual Reliance Initiatives Clinical Trials Not Allowed

PAR-25-003 04/01/2027

Agency HHS-FDA

High-priority technical directive issued by HHS-FDA. This initiative (ID: PAR-25-003) targets strategic development with...

Environmental influences on Child Health Outcomes (ECHO) Cohort Data and Biospecimen Access (X01 Clinical Trial Not Allowed)

PAR-25-437 03/01/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-437) targets strategic development wi...

Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)

RFA-FD-25-017 02/08/2028

Agency HHS-FDA

High-priority technical directive issued by HHS-FDA. This initiative (ID: RFA-FD-25-017) targets strategic development w...

Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2024, 2025, and 2026 (P50 Clinical Trial Required)

PAR-23-284 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-284) targets strategic development wi...

NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required)

PAR-23-287 10/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-287) targets strategic development wi...

NHLBI Program Project Applications (P01 Clinical Trials Optional)

PAR-24-065 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-065) targets strategic development wi...

National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional)

PAR-23-235 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-235) targets strategic development wi...

NIH Brain Development Cohorts (NBDC) Biospecimen Access (X01 Clinical Trial Not Allowed)

PAR-23-229 05/05/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-229) targets strategic development wi...

Cancer Research Education Grants Program - Courses for Skills Development (R25 Clinical Trial Not Allowed)

PAR-23-276 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-276) targets strategic development wi...

Cancer Research Education Grants Program - Research Experiences (R25 Clinical Trial Not Allowed)

PAR-23-277 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-277) targets strategic development wi...

Alcohol Research-Related Resource Award (R24 Clinical Trial Not Allowed)

PAR-24-071 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-071) targets strategic development wi...

Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)

PA-24-191 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-191) targets strategic development wit...

NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)

PA-24-193 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-193) targets strategic development wit...

BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional)

RFA-MH-25-110 06/24/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-MH-25-110) targets strategic development...

Focused Technology Research and Development (R01 Clinical Trial Not Allowed)

PAR-25-203 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-203) targets strategic development wi...

Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional)

PAR-25-227 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-227) targets strategic development wi...

Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)

PAR-25-038 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-038) targets strategic development wi...

Translational Neural Devices (R61/R33 - Clinical Trial Optional)

PAR-25-053 01/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-053) targets strategic development wi...

Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)

PAR-25-066 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-066) targets strategic development wi...

Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)

PA-24-254 07/12/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-254) targets strategic development wit...

Cancer Prevention and Control Clinical Trials Planning Grant Program (U34 Clinical Trials Optional)

PAR-25-103 10/25/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-103) targets strategic development wi...

Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)

PAR-25-202 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-202) targets strategic development wi...

Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

PAR-24-293 08/18/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-293) targets strategic development wi...

Emerging Global Leader Award (K43 Independent Clinical Trial Required)

PAR-24-295 12/03/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-295) targets strategic development wi...

Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)

PAR-25-145 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-145) targets strategic development wi...

Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders(U01 Clinical Trial Optional)

PAR-25-050 06/22/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-050) targets strategic development wi...

NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22 Clinical Trial Required)

PAR-24-211 07/12/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-211) targets strategic development wi...

Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)

PAR-25-256 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-256) targets strategic development wi...

Laboratories to Optimize Digital Health (R01 Clinical Trial Required)

PAR-25-136 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-136) targets strategic development wi...

Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)

PAR-25-273 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-273) targets strategic development wi...

NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Not Allowed)

PAR-25-027 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-027) targets strategic development wi...

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required)

PAR-24-312 07/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-312) targets strategic development wi...

Natural Product Multi-Site Clinical Trial Data Coordinating Center (Collaborative U24 Clinical Trial Required)

PAR-24-313 07/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-313) targets strategic development wi...

Mechanisms that Impact Cancer Risk after Bariatric Surgery (R01 Clinical Trial Optional)

PAR-25-043 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-043) targets strategic development wi...

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Neurotherapeutic Agent Characterization and In vivo Efficacy Studies (R61/R33 Clinical Trial Not Allowed)

PAR-25-225 10/20/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-225) targets strategic development wi...

NIDA Research Education Program for Clinical Researchers and Clinicians (R25 Clinical Trial Not Allowed)

PAR-25-204 11/12/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-204) targets strategic development wi...

BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional)

RFA-NS-25-022 09/28/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-25-022) targets strategic development...

Advancement and Innovation in Measurement of Language Development and Predictors (R01 Clinical Trial Not Allowed)

PAR-25-112 09/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-112) targets strategic development wi...

Limited Competition: Renewal of Existing NINDS-Supported Clinical Trial Cooperative Agreement Awards (U01 - Clinical Trials Required)

PAR-25-149 11/05/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-149) targets strategic development wi...

Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)

PAR-25-024 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-024) targets strategic development wi...

Advancement and Innovation in Measurement of Language Development and Predictors (R21 Clinical Trial Not Allowed)

PAR-25-113 09/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-113) targets strategic development wi...

NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

PAR-25-239 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-239) targets strategic development wi...

Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed)

PAR-25-131 04/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-131) targets strategic development wi...

Bioengineering Partnerships with Industry (U01 Clinical Trial Optional)

PAR-24-325 09/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-325) targets strategic development wi...

Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)

PAR-24-306 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-306) targets strategic development wi...

Limited Competition: Small Grant Program for ORIP Special Emphasis Research Career Award (SERCA) K01 Recipients (R03 Clinical Trial Not Allowed)

PAR-25-176 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-176) targets strategic development wi...

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)

PAR-24-264 06/01/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-264) targets strategic development wi...

Early Stage Testing of Pharmacologic or Neuromodulatory Device-based Interventions for the Treatment of Mental Disorders (R33- Clinical Trial Required)

PAR-25-183 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-183) targets strategic development wi...

Cancer Prevention and Control Clinical Trials Planning Grant Program (R34 Clinical Trials Optional)

PAR-25-104 10/25/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-104) targets strategic development wi...

NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)

PAR-25-052 11/19/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-052) targets strategic development wi...

NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)

PAR-24-301 09/25/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-301) targets strategic development wi...

Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R01 - Clinical Trial Optional)

PAR-25-265 11/16/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-265) targets strategic development wi...

Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed)

PAR-25-153 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-153) targets strategic development wi...

Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)

PAR-25-228 09/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-228) targets strategic development wi...

NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)

PAR-25-135 10/14/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-135) targets strategic development wi...

Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)

PAR-25-281 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-281) targets strategic development wi...

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

PAR-25-122 11/16/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-122) targets strategic development wi...

NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)

PAR-25-271 11/13/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-271) targets strategic development wi...

NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)

PAR-25-267 11/17/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-267) targets strategic development wi...

Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01 Clinical Trial Not Allowed)

PAR-25-248 10/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-248) targets strategic development wi...

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)

PAR-25-148 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-148) targets strategic development wi...

Catalyze Product Definition Medical Device prototype design/testing and disease target identification and assay development (R61/R33 - Clinical Trial Not Allowed)

RFA-HL-26-019 12/23/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HL-26-019) targets strategic development...

Molecular Imaging of Inflammation in Cancer (R01 Clinical Trial Not Allowed)

PAR-24-311 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-311) targets strategic development wi...

New Approaches for Measuring Brain Changes Across Longer Timespans (R21 Clinical Trial Optional)

PAR-25-272 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-272) targets strategic development wi...

Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)

PAR-24-268 01/27/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-268) targets strategic development wi...

NIAID Career Transition Award (K22 Independent Clinical Trial Not Allowed)

PAR-25-251 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-251) targets strategic development wi...

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed)

PAR-25-075 10/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-075) targets strategic development wi...

BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)

RFA-MH-26-170 02/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-MH-26-170) targets strategic development...

Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)

PAR-25-285 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-285) targets strategic development wi...

Full-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 - Clinical Trial Required)

PAR-25-177 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-177) targets strategic development wi...

NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22 Independent Clinical Trial Not Allowed)

PAR-24-209 07/12/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-209) targets strategic development wi...

Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)

PAR-25-181 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-181) targets strategic development wi...

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required)

PAR-24-275 07/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-275) targets strategic development wi...

Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)

PAR-25-255 11/05/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-255) targets strategic development wi...

Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)

PAR-25-207 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-207) targets strategic development wi...

Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)

PAR-25-229 09/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-229) targets strategic development wi...

NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)

PAR-25-105 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-105) targets strategic development wi...

NICHD Small Research Grant Program (R03 Clinical Trial Required)

PA-25-125 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-125) targets strategic development wit...

Alcohol Health Services Research (R01 Clinical Trial Optional)

PA-25-245 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-245) targets strategic development wit...

Alcohol Treatment, Pharmacotherapy, and Recovery Research (R01 Clinical Trial Required)

PA-25-163 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-163) targets strategic development wit...

NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)

RFA-OD-24-011 12/04/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-OD-24-011) targets strategic development...

Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional)

PAR-25-175 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-175) targets strategic development wi...

Innovative Programs to Enhance Research Training (IPERT) (R25 Independent Clinical Trial Not Allowed)

PAR-24-252 10/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-252) targets strategic development wi...

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)

PAR-25-134 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-134) targets strategic development wi...

HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)

RFA-NS-25-023 01/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-25-023) targets strategic development...

Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)

PAR-25-291 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-291) targets strategic development wi...

Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R34 Clinical Trial Required)

PAR-25-288 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-288) targets strategic development wi...

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

PAR-25-210 06/02/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-210) targets strategic development wi...

Alcohol Health Services Research (R34 Clinical Trial Optional)

PAR-25-192 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-192) targets strategic development wi...

Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)

PA-25-172 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-172) targets strategic development wit...

Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)

PA-25-253 09/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-253) targets strategic development wit...

Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional)

PAR-25-282 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-282) targets strategic development wi...

Imaging - Science Track Award for Research Transition (I/START) (R03 Clinical Trial Optional)

PAR-24-297 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-297) targets strategic development wi...

Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R34 Clinical Trial Optional)

PAR-25-159 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-159) targets strategic development wi...

Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R01 Clinical Trial Optional)

PAR-25-036 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-036) targets strategic development wi...

Summer Research Education Experience Program (R25 Clinical Trial Not Allowed)

PAR-24-204 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-204) targets strategic development wi...

New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional)

PAR-25-279 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-279) targets strategic development wi...

Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)

PAR-25-069 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-069) targets strategic development wi...

Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R01 Clinical Trial Required)

PAR-25-289 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-289) targets strategic development wi...

Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional)

PAR-25-310 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-310) targets strategic development wi...

NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)

PAR-24-269 02/11/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-269) targets strategic development wi...

Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)

PAR-25-185 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-185) targets strategic development wi...

Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

PAR-25-051 08/18/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-051) targets strategic development wi...

Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)

PAR-25-167 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-167) targets strategic development wi...

National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)

PAR-25-081 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-081) targets strategic development wi...

BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)

RFA-NS-25-021 09/28/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-25-021) targets strategic development...

Limited Competition: CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed)

PA-25-093 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-093) targets strategic development wit...

NIA Academic Leadership Career Award (K07 Independent Clinical Trial Not Allowed)

PAR-24-321 11/12/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-321) targets strategic development wi...

Limited Competition: Basic Instrumentation Grant (BIG) Program (S10 Clinical Trial Not Allowed)

PAR-24-326 06/01/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-326) targets strategic development wi...

Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)

PAR-25-178 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-178) targets strategic development wi...

Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)

PAR-25-179 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-179) targets strategic development wi...

BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)

RFA-MH-26-140 06/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-MH-26-140) targets strategic development...

NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)

PAR-25-025 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-025) targets strategic development wi...

Clinical and Translational Science Award (UM1 Clinical Trial Optional)

PAR-24-272 09/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-272) targets strategic development wi...

NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

PAR-25-188 01/06/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-188) targets strategic development wi...

Mechanisms that Impact Cancer Risk after Bariatric Surgery (R21 Clinical Trial Not Allowed)

PAR-25-044 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-044) targets strategic development wi...

NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)

PAR-25-026 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-026) targets strategic development wi...

Successor-in-Interest (Type 6 Parent Clinical Trial Optional)

PA-24-253 07/17/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-253) targets strategic development wit...

Basic Research in Cancer Health Disparities (R01 Clinical Trial Not Allowed)

PAR-25-243 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-243) targets strategic development wi...

Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required)

PAR-25-216 11/12/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-216) targets strategic development wi...

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)

PAR-25-211 06/02/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-211) targets strategic development wi...

Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)

PAR-25-297 11/05/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-297) targets strategic development wi...

Schizophrenia and related disorders during mid- to late-life (R21 Clinical Trial Optional)

PAR-25-040 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-040) targets strategic development wi...

Digital Health Technology Derived Biomarkers and Outcome Assessments for Remote Monitoring and Endpoint Development (UG3/UH3 - Clinical Trial Optional)

PAR-25-170 06/22/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-170) targets strategic development wi...

Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)

PAR-25-182 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-182) targets strategic development wi...

Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)

PAR-25-095 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-095) targets strategic development wi...

Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Not Allowed)

PAR-25-215 11/12/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-215) targets strategic development wi...

Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)

PAR-25-266 11/16/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-266) targets strategic development wi...

NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of Postdoctoral Fellows (F32 Clinical Trial Not Allowed)

PAR-25-234 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-234) targets strategic development wi...

Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01 Clinical Trial Optional)

PAR-25-065 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-065) targets strategic development wi...

Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed)

PAR-25-070 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-070) targets strategic development wi...

Toward Translation of Nanotechnology Cancer Interventions (TTNCI; R01 Clinical Trial Not Allowed)

PAR-25-336 11/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-336) targets strategic development wi...

NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)

PA-25-302 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-302) targets strategic development wit...

Limited Competition: Mentored Research Career Development Program Award in Clinical and Translational Science Awards (CTSA) Program (K12 Clinical Trial Optional)

PAR-25-196 09/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-196) targets strategic development wi...

Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)

PAR-25-091 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-091) targets strategic development wi...

NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required)

PAR-25-343 10/18/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-343) targets strategic development wi...

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Optional)

PAR-25-337 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-337) targets strategic development wi...

Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed)

PAR-25-377 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-377) targets strategic development wi...

Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required)

PAS-25-102 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAS-25-102) targets strategic development wi...

Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed)

PAR-25-194 09/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-194) targets strategic development wi...

Limited Competition: NCATS Clinical and Translational Science Award (CTSA) Program Research Education Grants Programs (R25 - Clinical Trial Not Allowed)

PAR-25-197 05/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-197) targets strategic development wi...

Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional)

PAR-25-299 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-299) targets strategic development wi...

Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed)

PAR-25-325 09/10/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-325) targets strategic development wi...

Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)

PAR-25-321 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-321) targets strategic development wi...

HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)

PAR-25-154 07/16/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-154) targets strategic development wi...

NEI Clinical Research Study Planning Grant Program (R34 Clinical Trial Not Allowed)

PAR-25-358 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-358) targets strategic development wi...

Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional)

PAR-25-296 10/19/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-296) targets strategic development wi...

NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

PAR-25-141 03/04/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-141) targets strategic development wi...

Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 - Clinical Trial Required)

PAR-25-342 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-342) targets strategic development wi...

HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

RFA-AT-25-003 11/23/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-AT-25-003) targets strategic development...

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)

PAR-25-353 10/25/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-353) targets strategic development wi...

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)

RFA-HG-25-009 02/26/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HG-25-009) targets strategic development...

Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)

PAR-24-330 09/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-330) targets strategic development wi...

NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)

PAR-25-357 10/16/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-357) targets strategic development wi...

NIDCD Research Grants for Translating Basic Research into Clinical Practice (R01 Clinical Trial Optional)

RFA-DC-25-002 10/12/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DC-25-002) targets strategic development...

Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed)

PAR-25-346 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-346) targets strategic development wi...

Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)

RFA-TR-25-002 06/02/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-TR-25-002) targets strategic development...

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)

PAR-24-280 11/02/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-280) targets strategic development wi...

NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)

PAR-25-032 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-032) targets strategic development wi...

Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional)

PAR-25-327 10/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-327) targets strategic development wi...

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-25-301 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-301) targets strategic development wit...

Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed)

PAR-25-374 05/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-374) targets strategic development wi...

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)

PAR-25-352 10/25/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-352) targets strategic development wi...

Method to Extend Research in Time (MERIT) Award Extension Request (Type 4 eSubmission Clinical Trial Optional)

PAR-25-324 09/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-324) targets strategic development wi...

BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)

RFA-EY-25-001 06/15/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-EY-25-001) targets strategic development...

Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)

PAR-25-283 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-283) targets strategic development wi...

Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

PAR-25-100 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-100) targets strategic development wi...

NIH Research Project Grant (Parent R01 Clinical Trial Required)

PA-25-305 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-305) targets strategic development wit...

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)

PAR-24-279 11/02/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-279) targets strategic development wi...

Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required)

RFA-DC-25-003 10/01/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DC-25-003) targets strategic development...

In Vivo High-Resolution Imaging for Inner Ear Visualization (R01 Clinical Trial optional)

RFA-DC-25-005 10/01/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DC-25-005) targets strategic development...

NCI Pathway to Independence Award (K99/R00 Clinical Trial Required)

PAR-25-313 10/14/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-313) targets strategic development wi...

Innovative Pilot Mental Health Services Research Not Involving Clinical Trials (R34 Clinical Trial Not Allowed)

PAR-25-284 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-284) targets strategic development wi...

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Not Allowed)

PAR-25-338 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-338) targets strategic development wi...

Modern Equipment for Shared-use Biomedical Research Facilities: Advancing Research-Related Operations (S15 Clinical Trial Not Allowed)

PAR-24-259 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-259) targets strategic development wi...

Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)

PAR-24-296 12/03/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-296) targets strategic development wi...

The Role of Work in Health Disparities in the U.S. (R01 Clinical Trials Optional)

PAR-25-292 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-292) targets strategic development wi...

Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)

PAR-25-290 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-290) targets strategic development wi...

Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

PAR-24-265 06/01/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-265) targets strategic development wi...

NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

PAR-25-269 11/13/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-269) targets strategic development wi...

Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)

PAR-25-158 11/17/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-158) targets strategic development wi...

Global Infectious Disease Research Training Program (D43 Clinical Trial Optional)

PAR-24-174 08/06/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-174) targets strategic development wi...

Catalyze: Product Definition Medical Device Prototype Optimization (R33 - Clinical Trial Not Allowed)

RFA-HL-26-020 12/23/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HL-26-020) targets strategic development...

CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)

PAR-25-077 10/16/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-077) targets strategic development wi...

NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

PAR-25-057 01/06/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-057) targets strategic development wi...

Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

PAR-25-442 02/17/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-442) targets strategic development wi...

Center of Excellence for Alternative Jet Fuels and Environment

FAA-COE-AJFE 09/30/2026

Agency DOT-FAA-FAA COE-AJFE

High-priority technical directive issued by DOT-FAA-FAA COE-AJFE. This initiative (ID: FAA-COE-AJFE) targets strategic d...

Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)

RFA-DA-26-034 11/18/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-26-034) targets strategic development...

NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

PA-25-304 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-304) targets strategic development wit...

NIA Expanding Research in AD/ADRD (ERA) Summer Research Education Program (R25 Independent Clinical Trial Not Allowed)

RFA-AG-26-011 05/26/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-AG-26-011) targets strategic development...

NIA Expanding Research in AD/ADRD (ERA) Postbaccalaureate Research Education Program (R25 Independent Clinical Trial Not Allowed)

RFA-AG-26-010 05/26/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-AG-26-010) targets strategic development...

NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

PA-25-306 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-306) targets strategic development wit...

Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)

RFA-ES-25-002 04/20/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-ES-25-002) targets strategic development...

Limited Competition: National Primate Research Centers (P51) (Clinical Trials Not Allowed)

PAR-23-126 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-126) targets strategic development wi...

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

PAR-25-446 08/21/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-446) targets strategic development wi...

Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed)

PAR-25-195 09/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-195) targets strategic development wi...

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)

PA-25-080 09/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-080) targets strategic development wit...

Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required)

PA-24-190 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-190) targets strategic development wit...

NIDCD Research Career Enhancement Award for Established Investigators (K18 Clinical Trial Not Allowed)

PAR-24-143 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-143) targets strategic development wi...

NINDS Research Education Opportunities (R25 Clinical Trial Not Allowed)

PAR-24-200 07/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-200) targets strategic development wi...

NEI Collaborative Clinical Vision Research Project: Coordinating Center Grant (UG1 Clinical Trial Required)

PAR-23-204 05/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-204) targets strategic development wi...

Process Systems, Reaction Engineering, and Molecular Thermodynamics

PD-23-1403 See Registry

High-priority technical directive issued by NSF. This initiative (ID: PD-23-1403) targets strategic development within t...

Engineering of Biomedical Systems

PD-23-5345 See Registry

High-priority technical directive issued by NSF. This initiative (ID: PD-23-5345) targets strategic development within t...

Utilizing Equipment to Study Environmental Extrinsic Factors and Enhance Rigor and Reproducibility of Animal Research (R24, Clinical Trials Not-Allowed)

PAR-24-167 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-167) targets strategic development wi...

Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)

PA-24-185 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-185) targets strategic development wit...

NIDCD Research Career Enhancement Award for Established Investigators (K18 Clinical Trial Required)

PAR-24-140 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-140) targets strategic development wi...

Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional)

PA-24-201 04/18/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-201) targets strategic development wit...

Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required)

PA-24-187 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-187) targets strategic development wit...

Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed)

PA-24-188 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-188) targets strategic development wit...

Building Interdisciplinary Research Careers in Women's Health (BIRCWH) (K12 Clinical Trial Optional)

RFA-OD-24-013 05/28/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-OD-24-013) targets strategic development...

NIDA Mentored Clinical Scientist Development Program Award in Substance Use and Substance Use Disorder Research (K12 Clinical Trial Optional)

PAR-24-089 11/13/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-089) targets strategic development wi...

Alcohol and Other Substance Use Research Education Programs for Health Professionals (R25 Clinical Trial Not Allowed)

PAR-23-240 05/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-240) targets strategic development wi...

NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed)

PAR-23-286 10/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-286) targets strategic development wi...

Cancer Research Education Grants Program - Curriculum or Methods Development (R25 Clinical Trial Not Allowed)

PAR-23-278 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-278) targets strategic development wi...

Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)

PA-23-317 11/24/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-23-317) targets strategic development wit...

Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional)

PAR-23-166 08/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-166) targets strategic development wi...

NEI Collaborative Clinical Vision Research Project: Resource Center Grant (UG1 Clinical Trial Required)

PAR-23-201 05/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-201) targets strategic development wi...

NEI Collaborative Clinical Vision Research: Chair's Grant (UG1-Clinical Trial Required)

PAR-23-209 05/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-209) targets strategic development wi...

Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01 Clinical Trial Not Allowed)

PAR-23-184 07/08/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-184) targets strategic development wi...

NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional)

RFA-HL-26-002 04/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HL-26-002) targets strategic development...

NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)

RFA-HL-26-003 04/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HL-26-003) targets strategic development...

NIDCD Mentored Career Development Award for Postdoctorate Au.D./Ph.D. Audiologists (K01 Clinical Trial Required)

PAR-24-149 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-149) targets strategic development wi...

Independent Scientist Award (Parent K02 - Independent Clinical Trial Required)

PA-24-178 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-178) targets strategic development wit...

NIDCD Mentored Career Development Award for Postdoctorate Au.D./Ph.D. Audiologists (K01 Independent Clinical Trial Not Allowed)

PAR-24-159 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-159) targets strategic development wi...

Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed)

PA-24-179 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-179) targets strategic development wit...

NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)

PA-24-194 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-194) targets strategic development wit...

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)

PAR-24-214 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-214) targets strategic development wi...

Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Research Centers (P50 Clinical Trial Optional)

PAR-24-210 05/18/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-210) targets strategic development wi...

D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional)

PAS-25-236 09/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAS-25-236) targets strategic development wi...

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed)

PAR-25-074 10/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-074) targets strategic development wi...

Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)

PA-24-176 05/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-176) targets strategic development wit...

Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21 Clinical Trial Optional)

PAR-25-064 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-064) targets strategic development wi...

Advancing Healthcare for Older Adults from Populations that Experience Health Disparities (R01 - Clinical Trial Optional)

PAR-24-273 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-273) targets strategic development wi...

Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U01 Clinical Trial Optional)

PAR-25-055 06/22/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-055) targets strategic development wi...

Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)

PAR-25-287 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-287) targets strategic development wi...

Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)

PAR-25-206 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-206) targets strategic development wi...

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Assay Development and Neurotherapeutic Agent Identification (R61/R33 Clinical Trial Not Allowed)

PAR-25-059 10/20/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-059) targets strategic development wi...

Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)

PAR-25-096 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-096) targets strategic development wi...

Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)

PAS-25-205 01/06/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAS-25-205) targets strategic development wi...

Catalyze: Enabling Technologies and Transformative Platforms for HLBS Research (R33 - Clinical Trials Not Allowed)

RFA-HL-26-016 12/23/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HL-26-016) targets strategic development...

Limited Competition: Building Partnerships and Broadening Perspectives to Advance Ethical, Legal, and Social Implications (ELSI) Research (BBAER) Program (UM1), Clinical Trial Optional

RFA-HG-24-026 08/02/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HG-24-026) targets strategic development...

Assay Development and Screening for Discovery of Validated Chemical Hits for Brain Disorders (R01 Clinical Trial Not Allowed)

PAR-25-063 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-063) targets strategic development wi...

Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)

PAR-25-226 11/19/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-226) targets strategic development wi...

Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) (R24 - Clinical Trial Not Allowed)

PAR-24-260 01/27/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-260) targets strategic development wi...

HIV Prevention and Alcohol (R34 Clinical Trials Optional)

PAS-25-161 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAS-25-161) targets strategic development wi...

First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)

PAR-25-180 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-180) targets strategic development wi...

Basic Research in Cancer Health Disparities (R21 Clinical Trial Not Allowed)

PAR-25-244 11/16/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-244) targets strategic development wi...

Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)

PAR-25-062 01/06/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-062) targets strategic development wi...

Early Stage Testing of Pharmacologic or Neuromodulatory Device-based Interventions for the Treatment of Mental Disorders (R61/R33 Clinical Trial Required)

PAR-25-184 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-184) targets strategic development wi...

Alcohol Treatment, Pharmacotherapy, and Recovery Research (R34 Clinical Trial required)

PAR-25-193 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-193) targets strategic development wi...

NIDCR Small Research Grants for Analyses of Existing Genomics Data (R03 Clinical Trial Not Allowed)

PAR-25-166 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-166) targets strategic development wi...

Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed)

PAR-24-304 10/14/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-304) targets strategic development wi...

Schizophrenia and related disorders during mid- to late-life (R01 Clinical Trial Optional)

PAR-25-039 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-039) targets strategic development wi...

BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)

RFA-MH-26-120 06/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-MH-26-120) targets strategic development...

Social disconnection and Suicide Risk in Late Life (R01 Clinical Trial Optional)

PAR-25-067 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-067) targets strategic development wi...

NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

PAR-25-270 11/13/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-270) targets strategic development wi...

NIDCR Research Grants for Analyses of Existing Genomics Data (R01) (Clinical Trial Not Allowed)

PAR-25-164 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-164) targets strategic development wi...

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)

PAR-25-060 10/20/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-060) targets strategic development wi...

Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed)

PAR-25-037 09/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-037) targets strategic development wi...

Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)

RFA-DA-26-055 12/03/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-26-055) targets strategic development...

Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems (R01 Clinical Trial Optional)

PAR-25-079 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-079) targets strategic development wi...

Standardizing Data and Metadata from Wearable Devices (R01 Clinical Trial Not Allowed)

PAR-24-250 06/10/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-250) targets strategic development wi...

Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)

RFA-DA-26-056 12/03/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-26-056) targets strategic development...

Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)

PAR-25-235 01/07/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-235) targets strategic development wi...

NIDCD Early Career Research(ECR) Award (R21 Clinical Trial Optional)

PAR-25-120 10/15/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-120) targets strategic development wi...

BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)

RFA-NS-24-031 01/28/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-24-031) targets strategic development...

Research Grants in Clinical Informatics (R01 Clinical Trial Optional)

PAR-26-042 03/05/2029

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-042) targets strategic development wi...

Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)

PAR-26-040 03/05/2029

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-040) targets strategic development wi...

BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)

RFA-NS-25-017 06/16/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-25-017) targets strategic development...

BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)

RFA-NS-25-018 06/16/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-25-018) targets strategic development...

Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)

PAR-25-322 08/25/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-322) targets strategic development wi...

Stimulating Access to Research in Residency (StARR) (R38 Independent Clinical Trial Not Allowed)

RFA-HL-26-012 01/10/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HL-26-012) targets strategic development...

Native American Research Centers for Health (NARCH) Planning Grants (R34 - Clinical Trial Not Allowed)

PAR-25-441 07/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-441) targets strategic development wi...

HT9425-23-S-SOC1 07/31/2028

BROAD AGENCY ANNOUNCEMENT (BAA) for Extramural Biomedical and Human Performance Research and Development Department of Defense

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT9425-23-S-SOC1) targets strategic developm...

BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)

RFA-DA-27-004 11/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-27-004) targets strategic development...

Community-Partnered Nursing Research Centers (P20 Clinical Trial Optional)

PAR-25-439 05/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-439) targets strategic development wi...

NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)

PAR-25-049 07/09/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-049) targets strategic development wi...

NCMRR Early Career Research Award (R03 Clinical Trial Optional)

PAR-25-124 01/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-124) targets strategic development wi...

Institutional Network Award for Promoting Kidney, Urologic, and Hematologic Research Training (U2C - Clinical Trial Not Allowed)

PAR-26-115 05/26/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-115) targets strategic development wi...

Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)

PAR-26-121 05/26/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-121) targets strategic development wi...

RFA-OD-25-010 09/28/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-OD-25-010) targets strategic development...

NIGMS Institutional Biomedical Undergraduate Research Training (BURT) Program (T34)

PAR-26-033 09/25/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-033) targets strategic development wi...

Single Source Renewal for the Continuation of the Liver Cirrhosis Network: Scientific and Data Coordination Center (U24 Clinical Trial Optional)

RFA-DK-26-309 01/27/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DK-26-309) targets strategic development...

Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)

PAR-25-444 09/25/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-444) targets strategic development wi...

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

PA-26-001 11/30/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-26-001) targets strategic development wit...

Diabetes Research Centers (P30 Clinical Trial Optional)

RFA-DK-26-310 01/27/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DK-26-310) targets strategic development...

Limited Competition Renewal for the Continuation of the Liver Cirrhosis Network: Clinical Research Centers (U01 Clinical Trial Required)

RFA-DK-26-308 03/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DK-26-308) targets strategic development...

Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)

PAR-26-116 03/06/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-116) targets strategic development wi...

NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

PAR-25-447 05/08/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-447) targets strategic development wi...

Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)

PAR-25-450 07/20/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-450) targets strategic development wi...

Accelerating Research through International Network-to-Network Collaborations

23-619 09/21/2026

High-priority technical directive issued by NSF. This initiative (ID: 23-619) targets strategic development within the P...

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

PAR-25-449 06/07/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-449) targets strategic development wi...

Early-Stage Dissemination and Implementation Research in Communication Disorders (R21 Clinical Trial Optional)

RFA-DC-26-001 06/17/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DC-26-001) targets strategic development...

National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)

PAR-26-138 01/26/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-138) targets strategic development wi...

BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)

RFA-NS-27-001 10/06/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-27-001) targets strategic development...

Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed)

RFA-AI-27-019 06/04/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-AI-27-019) targets strategic development...

NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)

PA-26-002 05/07/2029

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-26-002) targets strategic development wit...

Animal and Biological Material Resource Centers (P40) (Clinical Trials Not-Allowed)

RFA-OD-23-001 05/09/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-OD-23-001) targets strategic development...

Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)

PA-24-182 05/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-182) targets strategic development wit...

Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)

PA-24-181 05/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-181) targets strategic development wit...

Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)

PA-24-184 05/08/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-24-184) targets strategic development wit...

Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed)

RFA-RM-26-017 06/23/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-RM-26-017) targets strategic development...

The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)

PAR-26-134 11/22/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-134) targets strategic development wi...

A Science of Science Approach to Analyzing and Innovating the Biomedical Research Enterprise

23-569 09/09/2026

High-priority technical directive issued by NSF. This initiative (ID: 23-569) targets strategic development within the P...

High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

RFA-DA-25-060 03/05/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-25-060) targets strategic development...

High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)

RFA-DA-25-024 03/06/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-25-024) targets strategic development...

Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)

PAR-25-362 11/05/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-362) targets strategic development wi...

Advancing HIV/AIDS Research within the Mission of the NIDCD (R21 Clinical Trial Optional)

PAR-25-318 11/16/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-318) targets strategic development wi...

Advancing HIV/AIDS Research within the Mission of the NIDCD (R01 Clinical Trial Optional)

PAR-25-319 11/05/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-319) targets strategic development wi...

Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)

PAS-25-073 11/05/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAS-25-073) targets strategic development wi...

Annual Program Statement for U.S. Presentation at International Architecture Biennales

DFOP0017180 01/01/2099

Agency DOS-ECA

High-priority technical directive issued by DOS-ECA. This initiative (ID: DFOP0017180) targets strategic development wit...

Annual Program Statement for U.S. Presentation at International Art Biennales

DFOP0017204 01/01/2099

Agency DOS-ECA

High-priority technical directive issued by DOS-ECA. This initiative (ID: DFOP0017204) targets strategic development wit...

Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)

PAR-25-068 11/16/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-068) targets strategic development wi...

Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required)

PAR-24-329 03/16/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-329) targets strategic development wi...

Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)

PAR-27-013 11/02/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-013) targets strategic development wi...

Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)

PAR-27-012 11/02/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-012) targets strategic development wi...

Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)

PAR-27-011 11/02/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-011) targets strategic development wi...

NIMH Research Education Mentoring Program for HIV Researchers (R25 Clinical Trial Not Allowed)

PAR-24-233 05/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-233) targets strategic development wi...

Developmental AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)

PAR-24-164 05/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-164) targets strategic development wi...

AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)

PAR-24-165 05/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-165) targets strategic development wi...

Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research (U42 Clinical Trial Not Allowed)

PAR-24-129 09/25/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-129) targets strategic development wi...

Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed)

PAR-26-106 01/25/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-106) targets strategic development wi...

Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)

RFA-FD-25-020 05/16/2028

Agency HHS-FDA

High-priority technical directive issued by HHS-FDA. This initiative (ID: RFA-FD-25-020) targets strategic development w...

Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Not Allowed)

PA-25-150 05/07/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PA-25-150) targets strategic development wit...

NIDCD Clinical Research Center Grant (P50 Clinical Trial Optional)

PAR-25-445 10/03/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-445) targets strategic development wi...

Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)

RFA-OD-25-011 09/26/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-OD-25-011) targets strategic development...

Engineering Biological and Biomedical Systems (EBBS)

PD-26-369Y See Registry

High-priority technical directive issued by NSF. This initiative (ID: PD-26-369Y) targets strategic development within t...

USGS Earthquake Hazards Program External Research Support Announcement for Fiscal Year 2027

G27AS00075 06/04/2026

Agency DOI-USGS1

High-priority technical directive issued by DOI-USGS1. This initiative (ID: G27AS00075) targets strategic development wi...

Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype (R33 - Clinical Trial Not Allowed)

RFA-HL-26-018 12/23/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HL-26-018) targets strategic development...

Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)

RFA-HL-26-017 12/23/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-HL-26-017) targets strategic development...

Community-Based Participatory Research to Advance Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All (UG3/UH3 Clinical Trial Optional)

PAR-27-015 11/16/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-015) targets strategic development wi...

Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)

RFA-DE-27-001 10/19/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DE-27-001) targets strategic development...

Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)

RFA-MH-27-135 10/11/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-MH-27-135) targets strategic development...

HT942526ATRPTRA 10/22/2026

DoW Arthritis Translational Research Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526ATRPTRA) targets strategic developme...

Accelerating Product Excellence in Innovation and for Clinical Adoption (APEx) (U24 Clinical Trial Not Allowed)

RFA-DE-27-002 07/10/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DE-27-002) targets strategic development...

BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)

RFA-DC-27-004 02/11/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DC-27-004) targets strategic development...

Research Opportunities in Cancer Epidemiology Cohort Studies (U01 Clinical Trial Not Allowed)

PAR-27-073 07/05/2029

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-073) targets strategic development wi...

Bioengineering Research Grants (BRG) (R01 Clinical Trial Optional)

PAR-27-072 07/05/2029

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-072) targets strategic development wi...

HT942526OCRPCTA 10/01/2026

DoW Ovarian Cancer, Clinical Trial Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526OCRPCTA) targets strategic developme...

Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)

RFA-NS-26-001 11/10/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-NS-26-001) targets strategic development...

Coccidioidomycosis Collaborative Research Centers (P01 Clinical Trial Not Allowed)

RFA-AI-27-012 07/09/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-AI-27-012) targets strategic development...

Tuberculosis Research Advancement Centers (TRACs) (P30 Clinical Trial Not Allowed)

RFA-AI-27-016 07/10/2026

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-AI-27-016) targets strategic development...

Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

PAR-27-081 03/05/2027

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-081) targets strategic development wi...

HT942526VRPTRA 11/12/2026

DoW Vision, Translational Research Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526VRPTRA) targets strategic developmen...

HT942526LCRPTRA 09/02/2026

Lung Cancer Translational Research Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526LCRPTRA) targets strategic developme...

CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)

PAR-27-075 11/05/2028

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-075) targets strategic development wi...

HT942526ALSRPPCTA 09/30/2026

DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526ALSRPPCTA) targets strategic develop...

HT942526PCARPTRPA 10/07/2026

DoW Pancreatic Cancer Research Program, Translational Research Partnership Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526PCARPTRPA) targets strategic develop...

HT942526OCRPOCCTAECI 10/01/2026

DoW, Ovarian Cancer, Ovarian Cancer Clinical Trial Academy – Early-Career Investigator Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526OCRPOCCTAECI) targets strategic deve...

HT942526SCIRPCTA 11/12/2026

DoW Spinal Cord Injury, Clinical Trial Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526SCIRPCTA) targets strategic developm...

HT942526SCIRPTRA 11/12/2026

DoW Spinal Cord Injury, Translational Research Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526SCIRPTRA) targets strategic developm...

HT942526MSRPCTA 08/13/2026

DoW Multiple Sclerosis Clinical Trial Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526MSRPCTA) targets strategic developme...

HT942526VRPCTA 11/12/2026

DoW Vision, Clinical Trial Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526VRPCTA) targets strategic developmen...

NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)

PAR-27-077 05/25/2029

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-27-077) targets strategic development wi...

HT942526TSCRPCTRA 08/06/2026

DoW Tuberous Sclerosis Complex, Clinical Translational Research Award

High-priority technical directive issued by DOD-AMRAA. This initiative (ID: HT942526TSCRPCTRA) targets strategic develop...