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Mental Health Grants in South Carolina 2026 — Federal Funding Opportunities

Federal funding for mental health research, treatment programs, and behavioral health services from SAMHSA, NIMH, and HHS. GrantMetric surfaces every active federal notice of funding opportunity (NOFO) relevant to South Carolina applicants, with award ceiling, eligibility requirements, and close dates visible at a glance.

  • 41 active federal grants open to South Carolina organizations
  • Eligible applicants: nonprofits, universities, state agencies, small businesses
  • Award floor and ceiling for each funding opportunity
  • Application deadlines and close dates from grants.gov — updated daily
  • AI-generated briefings summarizing each program's objectives
Active Grants: 41 // State: South Carolina // Source: Grants.gov // Updated: Daily
Federal Grants in South Carolina

Federal grants are available nationally — South Carolina organizations apply directly to federal agencies. These 41 active opportunities are open to eligible applicants in South Carolina right now.

Federal mental health and behavioral health funding is distributed through SAMHSA (Substance Abuse and Mental Health Services Administration), NIMH (National Institute of Mental Health at NIH), and HRSA (Health Resources and Services Administration). SAMHSA's Community Mental Health Services Block Grant and Substance Abuse Prevention and Treatment Block Grant flow annually to the South Carolina state government, which sub-awards to community mental health centers, FQHCs, and nonprofit behavioral health providers across the state. Competitive SAMHSA grants — including Certified Community Behavioral Health Clinic (CCBHC) expansion awards, Crisis Services grants, and Minority AIDS Initiative grants — are open directly to qualifying organizations in South Carolina.

NIMH funds mental health research at academic institutions and research organizations in South Carolina, focusing on clinical trials, dissemination and implementation science, and research on evidence-based behavioral interventions. For South Carolina crisis services providers, SAMHSA's 988 Suicide and Crisis Lifeline funding, Crisis Stabilization Unit grants, and Mobile Crisis Team grants are critical federal revenue sources. HRSA's Behavioral Health Workforce Education and Training (BHWET) program funds universities and workforce training organizations in South Carolina to train behavioral health practitioners in shortage areas. Award amounts range from $250,000 annually for community grants to over $3 million for multi-year CCBHC expansion awards.

Active Opportunities for South Carolina (41)

PAR-25-286 01/07/2028
Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-286) targets strategic development wi...

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PAR-25-347 09/07/2026
Substance Use/Substance Use Disorder Dissertation Research Award (R36 Clinical Trials Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-347) targets strategic development wi...

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PAR-25-066 09/07/2026
Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-066) targets strategic development wi...

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PAR-25-285 10/15/2027
Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-285) targets strategic development wi...

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PAR-25-177 10/15/2027
Full-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 - Clinical Trial Required)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-177) targets strategic development wi...

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PAR-25-291 01/07/2028
Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-291) targets strategic development wi...

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PAR-25-288 01/07/2028
Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R34 Clinical Trial Required)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-288) targets strategic development wi...

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PAR-25-289 01/07/2028
Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R01 Clinical Trial Required)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-289) targets strategic development wi...

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PAR-25-310 01/07/2027
Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-310) targets strategic development wi...

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PAR-25-178 10/15/2027
Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-178) targets strategic development wi...

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PAR-25-040 09/07/2026
Schizophrenia and related disorders during mid- to late-life (R21 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-040) targets strategic development wi...

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PAR-25-065 09/07/2026
Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-065) targets strategic development wi...

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CDC-RFA-TP22-2201 02/11/2027
Public Health Crisis Response Cooperative Agreement
Agency HHS-CDC-OPHPR

High-priority technical directive issued by HHS-CDC-OPHPR. This initiative (ID: CDC-RFA-TP22-2201) targets strategic dev...

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PAR-25-283 01/07/2028
Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-283) targets strategic development wi...

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PAR-25-284 01/07/2028
Innovative Pilot Mental Health Services Research Not Involving Clinical Trials (R34 Clinical Trial Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-284) targets strategic development wi...

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PAR-25-290 01/07/2028
Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-290) targets strategic development wi...

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RFA-DA-26-034 11/18/2027
Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-26-034) targets strategic development...

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RFA-ES-25-002 04/20/2027
Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-ES-25-002) targets strategic development...

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PAR-25-446 08/21/2028
Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-446) targets strategic development wi...

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PAR-24-089 11/13/2026
NIDA Mentored Clinical Scientist Development Program Award in Substance Use and Substance Use Disorder Research (K12 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-089) targets strategic development wi...

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PAR-23-240 05/25/2026
Alcohol and Other Substance Use Research Education Programs for Health Professionals (R25 Clinical Trial Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-23-240) targets strategic development wi...

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PAR-25-064 09/07/2026
Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-064) targets strategic development wi...

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PAR-25-287 01/07/2028
Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-287) targets strategic development wi...

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PAR-25-180 10/15/2027
First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-180) targets strategic development wi...

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PAR-25-039 09/07/2026
Schizophrenia and related disorders during mid- to late-life (R01 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-039) targets strategic development wi...

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PAR-25-067 09/07/2026
Social disconnection and Suicide Risk in Late Life (R01 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-25-067) targets strategic development wi...

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RFA-DA-26-055 12/03/2027
Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-26-055) targets strategic development...

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RFA-DA-26-056 12/03/2027
Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-26-056) targets strategic development...

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VA-FOX-SP-FY2027 06/12/2026
Staff Sergeant Fox Suicide Prevention Grant Program Funding Opportunity
Agency VA-OMHSP

High-priority technical directive issued by VA-OMHSP. This initiative (ID: VA-FOX-SP-FY2027) targets strategic developme...

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CMS-2Q2-26-001 06/03/2026
Innovation in Behavioral Health (IBH)
Agency HHS-CMS

High-priority technical directive issued by HHS-CMS. This initiative (ID: CMS-2Q2-26-001) targets strategic development ...

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RFA-DA-25-060 03/05/2027
High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-25-060) targets strategic development...

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RFA-DA-25-024 03/06/2027
High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: RFA-DA-25-024) targets strategic development...

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PAR-24-164 05/25/2026
Developmental AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-164) targets strategic development wi...

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PAR-24-165 05/25/2026
AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)
Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-24-165) targets strategic development wi...

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O-BJA-2025-172498 05/27/2026
BJA FY25 De-escalation and Crisis Response Training Program
Agency USDOJ-OJP-BJA

High-priority technical directive issued by USDOJ-OJP-BJA. This initiative (ID: O-BJA-2025-172498) targets strategic dev...

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O-BJA-2025-172582 05/12/2026
BJA FY25 Byrne State Crisis Intervention Formula Program
Agency USDOJ-OJP-BJA

High-priority technical directive issued by USDOJ-OJP-BJA. This initiative (ID: O-BJA-2025-172582) targets strategic dev...

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TCEP-2027 05/31/2026
Tax Counseling for the Elderly (TCE)
Agency USDOT-IRS-TCE

High-priority technical directive issued by USDOT-IRS-TCE. This initiative (ID: TCEP-2027) targets strategic development...

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FR-6900-N-33 05/26/2026
Comprehensive Housing Counseling (CHC) and the Housing Counseling Training (HCT) NOFO (FY2025)
Agency HUD

High-priority technical directive issued by HUD. This initiative (ID: FR-6900-N-33) targets strategic development within...

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O-BJA-2025-172488 05/08/2026
BJA FY25 Second Chance Act Family-Based Substance Use Disorder Treatment Program
Agency USDOJ-OJP-BJA

High-priority technical directive issued by USDOJ-OJP-BJA. This initiative (ID: O-BJA-2025-172488) targets strategic dev...

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O-BJA-2025-172581 05/13/2026
BJA FY25 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Investigations Training and Technical Assistance (TTA)
Agency USDOJ-OJP-BJA

High-priority technical directive issued by USDOJ-OJP-BJA. This initiative (ID: O-BJA-2025-172581) targets strategic dev...

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O-BJA-2025-172485 05/08/2026
BJA FY25 Comprehensive Opioid, Stimulant, and Substance Use, Site-Based Program
Agency USDOJ-OJP-BJA

High-priority technical directive issued by USDOJ-OJP-BJA. This initiative (ID: O-BJA-2025-172485) targets strategic dev...

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Frequently Asked Questions

What mental health grants are available in South Carolina?
SAMHSA distributes Community Mental Health Services Block Grants to states, which South Carolina allocates to local providers. Federally Qualified Health Centers (FQHCs), community mental health centers, and nonprofits in South Carolina can also apply directly to SAMHSA competitive grants.
Can South Carolina crisis centers get federal funding?
Yes. SAMHSA provides funding to states to staff and operate the 988 Suicide & Crisis Lifeline. Crisis centers, behavioral health organizations, and state agencies in South Carolina can apply for operational funding through SAMHSA's crisis services portfolio.
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GrantMetric Intelligence Systems — Independent federal grant intelligence platform. Not affiliated with Grants.gov, the U.S. Department of Health & Human Services, or any government agency. Grant data is sourced from the Grants.gov API for informational purposes only; always verify opportunity details directly with the funding agency before applying. Some links on this site are affiliate links — we may earn a commission at no additional cost to you. Full Disclaimer  ·  Last Reviewed: May 2026  ·  Data Methodology