GrantMetric / States / North Carolina / SBIR & Small Business Grants
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SBIR & Small Business Grants in North Carolina 2026 — Federal Funding Opportunities

SBIR and STTR grants for small businesses and startups from NIH, NSF, DOD, DOE, and NASA. Phase I up to $300K, Phase II up to $2M. GrantMetric surfaces every active federal notice of funding opportunity (NOFO) relevant to North Carolina applicants, with award ceiling, eligibility requirements, and close dates visible at a glance.

  • 38 active federal grants open to North Carolina organizations
  • Eligible applicants: nonprofits, universities, state agencies, small businesses
  • Award floor and ceiling for each funding opportunity
  • Application deadlines and close dates from grants.gov — updated daily
  • AI-generated briefings summarizing each program's objectives
Active Grants: 38 // State: North Carolina // Source: Grants.gov // Updated: Daily
Federal Grants in North Carolina

Federal grants are available nationally — North Carolina organizations apply directly to federal agencies. These 38 active opportunities are open to eligible applicants in North Carolina right now.

North Carolina — SBIR & Small Business Grants Intelligence

38 active sbir & small business grants currently open to North Carolina applicants on Grants.gov. Funding agencies: HHS-NIH11, DOS-CPV, DOD-AMC, NSF, NASA-HQ, DOD-ONR-NRL. Largest award ceiling: $16.0M. 3 grants closing within 30 days.

Federal grants are open nationally — North Carolina nonprofits, state agencies, universities, small businesses, and local governments apply directly to the funding agency. Eligibility requirements, award floors and ceilings, and application deadlines are listed on each opportunity's detail page. All data is sourced from Grants.gov and updated daily. Use the grant cards below to review open solicitations and click through to the full Notice of Funding Opportunity (NOFO) before applying.

Active Opportunities for North Carolina (38)

PAR-26-001 05/07/2027
Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required)
Agency HHS-NIH11

The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Of...

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PAR-25-311 11/15/2027
Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)
Agency HHS-NIH11

The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure r...

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PAR-25-383 01/28/2028
Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)
Agency HHS-NIH11

The purpose of this announcement is to encourage investigators to pursue translational activities and clinical feasibili...

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PAR-24-293 08/18/2027
Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)
Agency HHS-NIH11

The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic di...

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PAR-25-145 01/07/2028
Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)
Agency HHS-NIH11

The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to add...

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PAR-24-211 07/12/2027
NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22 Clinical Trial Required)
Agency HHS-NIH11

The purpose of the NHLBI Career Transition Award (K22) program is to provide highly qualified postdoctoral fellows in th...

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PAR-25-207 01/07/2028
Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
Agency HHS-NIH11

NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interven...

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PAR-25-025 01/07/2027
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)
Agency HHS-NIH11

The objective of this funding opportunity is to support investigator-initiated, phase I clinical trials for diagnostic a...

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PAR-25-026 01/07/2027
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)
Agency HHS-NIH11

The objective of this funding opportunity is to support investigator-initiated, Phase I clinical trials for diagnostic a...

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PAR-25-211 06/02/2027
Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)
Agency HHS-NIH11

The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to acceler...

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PAR-25-297 11/05/2027
Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)
Agency HHS-NIH11

The goal of this Notice of Funding Opportunity (NOFO) is to provide funding support for the pre-clinical and early stage...

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PAR-25-032 01/07/2027
NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)
Agency HHS-NIH11

This Notice of Funding Opportunity Announcement (NOFO) intends to supports studies that are both necessary and sufficien...

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AFPRA-20-04 See Registry
U.S. Embassy Praia Ambassador’s Special Self-Help (SSH) Program
Agency DOS-CPV

U.S. Embassy Praia welcomes the submission of project applications for funding through the Ambassador’s Special Self-H...

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W911NF-22-S-0011 See Registry
Tactical Behaviors for Autonomous Maneuver
Agency DOD-AMC

**UPDATE 5 APRIL 2024: The proposal submission date has been updated to 24 April 2024. The FOA has been amended to refle...

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W911NF-23-S-0003 01/04/2028
DEVCOM ANALYSIS CENTER BROAD AGENCY ANNOUNCEMENT FOR APPLIED RESEARCH
Agency DOD-AMC

The purpose of this Broad Agency Announcement (BAA) under Federal Acquisition Regulation (FAR) Part 35 and Funding Oppor...

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PAR-25-206 01/07/2028
Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
Agency HHS-NIH11

NIMH seeks applications for pilot effectiveness projects to evaluate the preliminary effectiveness of therapeutic and se...

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PAR-25-180 10/15/2027
First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)
Agency HHS-NIH11

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage cooperative agreement applications to support e...

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24-527 02/08/2027
GROWING CONVERGENCE RESEARCH
Agency NSF

Convergence research is a means for solving vexing research problems, in particular, complex problems focusing on societ...

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26-501 See Registry
Collaboratory to Advance Mathematics Education and Learning (CAMEL) for K-12
Agency NSF

The Collaboratory to Advance Mathematics Education and Learning (CAMEL) for K-12 initiative aims to advance mathematics ...

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NNH26ZTR001N See Registry
Space Technology Research, Development, Demonstration, and Infusion (SpaceTech REDDI-2026)
Agency NASA-HQ

The National Aeronautics and Space Administration (NASA) Headquarters, Space Technology Mission Directorate (STMD) will ...

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25-549 See Registry
NSF National Innovation Corps Teams (NSF National I-Corps (TM) Teams) program
Agency NSF

The U.S. National Science Foundation (NSF) continues to develop and nurture a national innovation ecosystem that guides ...

Technology View Details →
PD-98-1331 See Registry
Sociology
Agency NSF

The Sociology Program supports basic research on all forms of human social organization - societies, institutions, group...

Technology View Details →
PA-27-102 04/05/2027
NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
Agency HHS-NIH11

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PA-27-101 04/05/2029
NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
Agency HHS-NIH11

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PA-27-100 04/05/2027
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
Agency HHS-NIH11

Health View Details →
PAR-27-098 04/05/2029
SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
Agency HHS-NIH11

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PD-23-221Y See Registry
Growing Research Access for Nationally Transformative Economic Development
Agency NSF

NSF GRANTED supports innovative models of research enterprise administrative development and workforce training infrastr...

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PD-26-369Y See Registry
Engineering Biological and Biomedical Systems (EBBS)
Agency NSF

The Engineering Biological and Biomedical Systems (EBBS) program expands our understanding of biological and physiologic...

Technology View Details →
NNH26ZTR001N-26NIAC-A2 See Registry
NASA Innovative Advanced Concepts (NIAC) Phase II
Agency NASA-HQ

The National Aeronautics and Space Administration (NASA) Headquarters anticipates release of a solicitation, titled “N...

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W911NF-20-S-0008 03/31/2027
UNITED STATES MILITARY ACADEMY Broad Agency Announcement
Agency DOD-AMC

The U.S. Military Academy at West Point's mission is "to educate, train, and inspire the Corps of Cadets so that each gr...

Defense View Details →
N00173-24-S-BA01 09/30/2026
NRL Long Range Broad Agency Announcement (BAA) for Basic and Applied Research
Agency DOD-ONR-NRL

Amendment 0006 The purpose of this amendment is to extend the due date for acceptance of White Papers. All other terms a...

Defense View Details →
HT942526PRCRPCTA 10/05/2026
DoW Peer Reviewed Cancer, Clinical Trial Award
Agency DOD-AMRAA

Summary: The fiscal year 2026 (FY26) Peer Reviewed Cancer Research Program (PRCRP) Clinical Trial Award (CTA) supports t...

Defense View Details →
DE-FOA-0003612 12/17/2026
The Genesis Mission: Transforming Science and Energy with AI
Agency PAMS-SC

The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Manage...

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SB-OEDCS-26-002 09/04/2026
MANUFACTURING AND SMALL BUSINESS CYBERSECURITY RESILIENCE PROGRAM 2026
Agency SBA

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26-511 11/04/2026
NSF Small Business Innovation Research / Small Business Technology Transfer Phase I, Phase II, Fast-Track Programs: A Pilot Emphasis on Scientific Instrumentation
Agency NSF

NSF invests in scientific discoveries, technological breakthroughs, and transformative innovations that strengthen econo...

Technology View Details →
PAR-27-072 07/05/2029
Bioengineering Research Grants (BRG) (R01 Clinical Trial Optional)
Agency HHS-NIH11

This Notice of Funding Opportunity (NOFO) encourages collaborations between the life and physical sciences that: 1) appl...

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23-595 12/04/2026
Centers of Research Excellence in Science and Technology (CREST)
Agency NSF

CREST Center awards provide support to enhance the research capabilities of Minority-serving institutions (MSIs) through...

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DOS-SAU-2605-PD 09/14/2026
U.S-Saudi AI Research Commercialization Accelerator Program (ReCAP)
Agency DOS-SAU

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Frequently Asked Questions

Can North Carolina small businesses apply for SBIR?
Yes. Any U.S. small business (under 500 employees) with its primary place of business in North Carolina is eligible to apply for SBIR and STTR grants. Eleven federal agencies run SBIR programs including NIH, NSF, DOD, DOE, and NASA.
Are there SBIR resources specific to North Carolina?
Many states including North Carolina have SBIR/STTR outreach programs through their economic development offices. These state programs often offer matching funds, proposal assistance, and connections to federal program managers.
More Grant Topics in North Carolina
🔬 Cancer Research Grants 💬 Mental Health Grants ⚡ Climate & Clean Energy Grants 🤖 AI & Technology Grants 🏥 Public Health Grants 🧬 Biomedical Research Grants 🌾 Rural & Agriculture Grants 🎓 Education & Workforce Grants 🏘️ Housing & Community Grants
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GrantMetric Intelligence Systems — Independent federal grant intelligence platform. Not affiliated with Grants.gov, the U.S. Department of Health & Human Services, or any government agency. Grant data is sourced from the Grants.gov API for informational purposes only; always verify opportunity details directly with the funding agency before applying. Some links on this site are affiliate links — we may earn a commission at no additional cost to you. Full Disclaimer  ·  Last Reviewed: May 2026  ·  Data Methodology