SBIR & Small Business Grants in Missouri 2026 — Federal Funding Opportunities

SBIR and STTR grants for small businesses and startups from NIH, NSF, DOD, DOE, and NASA. Phase I up to $300K, Phase II up to $2M. GrantMetric surfaces every active federal notice of funding opportunity (NOFO) relevant to Missouri applicants, with award ceiling, eligibility requirements, and close dates visible at a glance.

2 active federal grants open to Missouri organizations
Eligible applicants: nonprofits, universities, state agencies, small businesses
Award floor and ceiling for each funding opportunity
Application deadlines and close dates from grants.gov — updated daily
AI-generated briefings summarizing each program's objectives

Active Grants: 2 // State: Missouri // Source: Grants.gov // Updated: Daily

Federal Grants in Missouri

Federal grants are available nationally — Missouri organizations apply directly to federal agencies. These 2 active opportunities are open to eligible applicants in Missouri right now.

The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs collectively represent over $4 billion in annual federal R&D investment directed to early-stage U.S. small businesses. Missouri companies qualify for SBIR awards across eleven participating agencies: NIH funds health technology, diagnostics, and medical devices; NSF funds any high-risk, high-reward technology; DOD funds dual-use defense applications; DOE funds energy and materials science; NASA funds aerospace and Earth observation technology. Phase I awards up to $300,000 fund technical feasibility research, while Phase II awards up to $2 million fund full prototype development and validation. Missouri companies in the midwest region have collectively received hundreds of millions in cumulative SBIR and STTR funding.

The STTR variant requires formal collaboration between a qualifying small business and a U.S. research institution, with at least 30% of the work performed by the research partner. Missouri's universities and federal research laboratories are active STTR partners — technology transfer offices at major institutions actively seek startup collaborations for STTR submissions. State-level SBIR support programs available in many U.S. states, including those operating in Missouri, offer proposal development assistance, matching funds, and Phase 0 feasibility awards to help first-time applicants build competitive submissions. The SBA's America's Seed Fund portal lists all open SBIR solicitations by agency and technology topic area.

Active Opportunities for Missouri (2)

PAR-26-001 05/07/2027

Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required)

Agency HHS-NIH11

High-priority technical directive issued by HHS-NIH11. This initiative (ID: PAR-26-001) targets strategic development wi...

Health View Details →

DE-FOA-0003539 05/20/2026

Fiscal Year 2026 Phase II Continuation Consolidated Innovative Nuclear Research

Agency DOE-ID

High-priority technical directive issued by DOE-ID. This initiative (ID: DE-FOA-0003539) targets strategic development w...

Energy View Details →

Frequently Asked Questions

Can Missouri small businesses apply for SBIR?

Yes. Any U.S. small business (under 500 employees) with its primary place of business in Missouri is eligible to apply for SBIR and STTR grants. Eleven federal agencies run SBIR programs including NIH, NSF, DOD, DOE, and NASA.

Are there SBIR resources specific to Missouri?

Many states including Missouri have SBIR/STTR outreach programs through their economic development offices. These state programs often offer matching funds, proposal assistance, and connections to federal program managers.